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Decitabine induces -mediated immune responses in p53-mutated triple-negative breast cancer: a clinical

Frontiers of Medicine doi: 10.1007/s11684-023-1016-8

Abstract: Here, we reposition decitabine for triple-negative breast cancer (TNBC), a subtype with frequent p53In a prospective DEciTabinE and Carboplatin in TNBC (DETECT) trial (NCT03295552), decitabine with carboplatinIn the DETECT trial, decitabine induced strong immune responses featuring the striking upregulation ofOur integrative studies reveal the potential of repurposing decitabine for the treatment of p53-mutatedTNBC and suggest IRF7 as a potential biomarker for decitabine-based treatments.

Keywords： p53 mutation     triple-negative breast cancer     decitabine     DNMT1     IRF7     innate immune response    

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Decitabine induces -mediated immune responses in p53-mutated triple-negative breast cancer: a clinical

Journal Article